Publications

2026

Out-of-equilibrium sensing with a chemically fueled molecular machine

17.

M.-C. Temian, B. M. W. Roberts, S. Borsley, F. della Sala, Z. Ashbridge & D. A. Leigh

Chem in press. (2026). DOI: XXXXXX

Near-quantitative formation of imines in water with allosteric control

16.

T. Marchetti, L. Goldin, B. M. W. Roberts, Deepak, F. Rastrelli, L. Gabrielli & L. J. Prins

J. Am. Chem. Soc. (2026). DOI: 10.1021/jacs.5c20524

Chiral catalysis-driven rotary molecular motors

15.

H. Liu, B. M. W. Roberts, S. Borsley, R. W. Adams, G. F. S. Whitehead, A. Hasija & D. A. Leigh

Nat. Chem. (2026). DOI: 10.1038/s41557-025-02050-0

2025

An information ratchet improves selectivity in DNA duplex formation under nonequilibrium conditions

14.

B. M. W. Roberts, E. del Grosso, E. Penocchio F. Ricci & L. J. Prins

Nat. Nanotechnol. 20, 1449–1456 (2025). DOI: 10.1038/s41565-025-01982-5

In Situ Quantification of Directional Rotation by a Catalysis-Driven Azaindole-N-Oxide–Phenoic Acid Molecular Motor

13.

H. Liu, A. Troncossi, B. M. W. Roberts, S. Borsley & D. A. Leigh

J. Am. Chem. Soc 147, 29534–29541 (2025). DOI: 10.1021/jacs.5c10520

2025 JACS Fuel promotor variation TOC.png

Structural influence of the chemical fueling system on a catalysis-driven rotary molecular motor

12.

H. Liu, T. W. Mrad, A. Troncossi, S. Borsley, B. M. W. Roberts, A. Betts & D. A. Leigh

J. Am. Chem. Soc 147, 8785–8795 (2025). DOI: 10.1021/jacs.5c00028

2024

Molecular ratchets and kinetic asymmetry: giving chemistry direction

11.

S. Borsley, D. A. Leigh & B. M. W. Roberts

Angew. Chem. Int. Ed. 63, e202400495 (2024). DOI: 10.1002/anie.202400495

A minimalistic covalent bond-forming cycle that consume adenosine diphosphate

10.

T. Marchetti, B. M. W. Roberts, D. Frezzato & L. J. Prins

Angew. Chem. Int. Ed. 63, e202402965 (2024). DOI: 10.1002/anie.202402965

Ratcheting synthesis

9.

S. Borsley, J. M. Gallagher, D. A. Leigh & B. M. W. Roberts

Nat. Rev. Chem. 8, 8–29 (2024). DOI: 10.1038/s41570-023-00558-y

Conformational selection accelerates catalysis by an organocatalytic molecular motor

8.

J. M. Gallagher, B. M. W. Roberts, S. Borsley & D. A. Leigh

Chem 10, 855–866, (2024). 10.1016/j.chempr.2023.10.019

2023

The role of kinetic asymmetry and power strokes in an information ratchet

7.

L. Binks, S. Borsley, T. R. Gingrich, D. A. Leigh, E. Penocchio, & B. M. W. Roberts

Chem 9, 2902–2917 (2023). DOI: 10.1016/j.chempr.2023.05.035

2022

Using catalysis to drive chemistry away from equilibrium: Relating kinetic asymmetry, power strokes and the Curtin-Hammett principle in Brownian ratchets

6.

S. Amano, M. Esposito, E. Kreidt, D. A. Leigh, E. Penocchio & B. M. W. Roberts

J. Am. Chem. Soc. 144, 20153–20164 (2022). DOI: 10.1021/jacs.2c08723

Tuning the force, speed and efficiency of an autonomous chemically-fueled information ratchet

5.

S. Borsley, D. A. Leigh, B. M. W. Roberts & I. J. Vitorica-Yrezabal

J. Am. Chem. Soc. 144, 17241–17248 (2022). DOI: 10.1021/jacs.2c07633

4. Chemical fuels for molecular machinery

S. Borsley, D. A. Leigh & B. M. W. Roberts

Nat. Chem. 14, 728–738 (2022). DOI: 10.1038/s41557-022-00970-9

Insights from an information thermodynamics analysis of a synthetic molecular motor

3.

S. Amano, M. Esposito, E. Kreidt, D. A. Leigh, E. Penocchio & B. M. W. Roberts

Nat. Chem. 14, 530–537 (2022). DOI: 10.1038/s41557-022-00899-z

Autonomous chemically fuelled directional rotation about a covalent single bond

2.

S. Borsley, D. A. Leigh, E. Kreidt, & B. M. W. Roberts

Nature 604, 80–85 (2022). DOI: 10.1038/s41586-022-04450-5

2021

A doubly kinetically-gated information ratchet autonomously driven by carbodiimide hydration

1.

S. Borsley, D. A. Leigh & B. M. W. Roberts

J. Am. Chem. Soc. 143, 4414–4420 (2021). DOI: 10.1021/jacs.1c01172